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1

(Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators

Sharma, Shiv K., Wu, Yu, Steinbergs, Nora, Crowley, Michael L., Hanson, Allison S., Casero, Robert A., Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.26 MB

english, 2010

2

Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 Years of Excellence

Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 679 KB

english, 2009

3

ChemInform Abstract: Terminally Alkylated Polyamine Analogues as Chemotherapeutic Agents

Robert A. Casero Jr., Patrick M. Woster

Journal:

Year:

2001

File:

PDF, 23 KB

2001

4

ChemInform Abstract: Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity.

Yu Zou, Zhiqian Wu, Nilantha Sirisoma, Patrick M. Woster, Robert A. Casero Jr., Louis M. Weiss, Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

Journal:

Year:

2001

File:

PDF, 27 KB

2001

5

ChemInform Abstract: Recent Advances in the Development of Polyamine Analogues as Antitumor Agents

Robert A. Jr. Casero, Patrick M. Woster

Journal:

Year:

2009

File:

PDF, 15 KB

2009

6

Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase

Ronghui Wu, Nada H. Saab, Huatao Huang, Laurie Wiest, Anthony E. Pegg, Robert A. Casero Jr, Patrick M. Woster

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 1.08 MB

english, 1996

7

Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolites of sulphamethoxazole and dapsone in normal human keratinocytes

Farah D. Khan, Sanjoy Roychowdhury, Radita Nemes, Piyush M. Vyas, Patrick M. Woster, Craig K. Svensson

Journal:

Year:

2006

Language:

english

File:

PDF, 353 KB

english, 2006

8

Synthesis of protected allylic amines via palladium(0)-catalyzed amination of allylic acetates

Nilantha S. Sirisoma, Patrick M. Woster

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 188 KB

english, 1998

9

Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity

Yu Zou, Zhiqian Wu, Nilantha Sirisoma, Patrick M Woster, Robert A Casero Jr., Louis M Weiss, Donna Rattendi, Schennella Lane, Cyrus J Bacchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

10

α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase

Yong Qian Wu, Timothy Lawrence, Jun Qing Guo, Patrick M. Woster

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 386 KB

english, 1993

11

Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents

Jun Qing Guo, Yong Qian Wu, Wayne L. Farmer, Kirk A. Douglas, Patrick M. Woster, Joanne Garofalo, Cyrus J. Basshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 465 KB

english, 1993

12

Restricted rotation analogs of decarboxylated S-adenosylmethionine as inhibitors of polyamine biosynthesis.

Kirk A. Douglas, Michele M. Zormeier, Lisa M. Marcolina, Patrick M. Woster

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1991

Language:

english

File:

PDF, 273 KB

english, 1991

13

Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Frank H. Bellevue III, Michelle Boahbedason, Ronghui Wu, Patrick M. Woster, Robert A. Casero Jr., Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 310 KB

english, 1996

14

Synthesis and biological evaluation of 6′,7′-dihydroxybergamottin (6,7-DHB), a naturally occurring inhibitor of cytochrome P450 3A4

Frank H. Bellevue III, Patrick M. Woster, David J. Edwards, Kan He, Paul F. Hollenberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 289 KB

english, 1997

15

Preparation of the pure diastereomeric forms of S- (5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2- cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli

Yong Qian Wu, Patrick M. Woster

Journal:

Bioorganic & Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.38 MB

english, 1993

16

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions 1

Reilly, Timothy P., Lash, Lawrence H., Doll, Mark A., Hein, David W., Woster, Patrick M., Svensson, Craig K.

Journal:

The Journal of Investigative Dermatology

Year:

2000

Language:

english

File:

PDF, 612 KB

english, 2000

17

Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity

Yanlin Wang, Amy Hacker, Tracy Murray-Stewart, Benjamin Frydman, Aldonia Valasinas, Alison V. Fraser, Patrick M. Woster, Robert A. Casero

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 336 KB

english, 2005

18

The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines

Allison Pledgie-Tracy, Madhavi Billam, Amy Hacker, Michele D. Sobolewski, Patrick M. Woster, Zhe Zhang, Robert A. Casero, Nancy E. Davidson

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 694 KB

english, 2010

19

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells

Qingsong Zhu, Yi Huang, Laurence J. Marton, Patrick M. Woster, Nancy E. Davidson, Robert A. Casero

Journal:

Year:

2012

Language:

english

File:

PDF, 657 KB

english, 2012

20

Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increasedN1,N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells

Alison V. Fraser, Andrew C. Goodwin, Amy Hacker-Prietz, Elizabeth Sugar, Patrick M. Woster, Robert A. Casero

Journal:

Year:

2012

Language:

english

File:

PDF, 433 KB

english, 2012

21

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

Xiangdong Bi, Christina Lopez, Cyrus J. Bacchi, Donna Rattendi, Patrick M. Woster

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 123 KB

english, 2006

22

Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

Gupta, Deepak, Yedidi, Ravikiran S., Varghese, Sheeba, Kovari, Ladislau C., Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

23

ChemInform Abstract: Polyamine Drug Discovery. Synthetic Approaches to Therapeutic Modulators of Polyamine Metabolism

Patrick M. Woster

Journal:

Year:

2012

File:

PDF, 18 KB

2012

24

Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes

Piyush M. Vyas, Sanjoy Roychowdhury, Patrick M. Woster, Craig K. Svensson

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 556 KB

english, 2005

25

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells

Laura Susick, Thulani Senanayake, Rajakrishnan Veluthakal, Patrick M. Woster, Anjaneyulu Kowluru

Journal:

Journal of Cellular and Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 755 KB

english, 2009

26

Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm

Manuela Cervelli, Gabriella Bellavia, Emiliano Fratini, Roberto Amendola, Fabio Polticelli, Marco Barba, Rodolfo Federico, Fabrizio Signore, Giacomo Gucciardo, Rosalba Grillo, Patrick M Woster, Robert

Journal:

Year:

2010

Language:

english

File:

PDF, 1.20 MB

english, 2010

27

Structural Specificity of Polyamines and Polyamine Analogues in the Protection of DNA from Strand Breaks Induced by Reactive Oxygen Species

Hyo Chol Ha, James D. Yager, Patrick A. Woster, Robert A. Casero Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 297 KB

english, 1998

28

Molecular basis for the polyamine-OmpF porin interactions: inhibitor and mutant studies

Ramkumar Iyer, Zhiqian Wu, Patrick M Woster, Anne H Delcour

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 324 KB

english, 2000

29

Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene (AdoMac)

Yong Qian Wu, Patrick M. Woster

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 901 KB

english, 1995

30

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

Ravikiran S. Yedidi, Zhigang Liu, Yong Wang, Joseph S. Brunzelle, Iulia A. Kovari, Patrick M. Woster, Ladislau C. Kovari, Deepak Gupta

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 600 KB

english, 2012

31

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

Yanlin Wang, Tracy Murray-Stewart, Wendy Devereux, Amy Hacker, Benjamin Frydman, Patrick M. Woster, Robert A. Casero Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

32

Comparison of the In Vitro Cytotoxicity of Hydroxylamine Metabolites of Sulfamethoxazole and Dapsone

Timothy P Reilly, Frank H Bellevue III, Patrick M Woster, Craig K Svensson

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 452 KB

english, 1998

33

Terminally Alkylated Polyamine Analogues as Chemotherapeutic Agents

Casero, Robert A., Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 603 KB

english, 2001

34

Solid Phase Synthesis. Edited by Kevin Burgess. Wiley Interscience, New York. 2000. xiv + 277 pp. 15.5 × 23.5 cm. ISBN 0471318256. $69.95.

Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 24 KB

english, 2001

35

Discovery of Novel Alkylated (bis)Urea and (bis)Thiourea Polyamine Analogues with Potent Antimalarial Activities

Verlinden, Bianca K., Niemand, Jandeli, Snyman, Janette, Sharma, Shiv K., Beattie, Ross J., Woster, Patrick M., Birkholtz, Lyn-Marie

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.21 MB

english, 2011

36

Polyamines and cancer: implications for chemotherapy and chemoprevention

Nowotarski, Shannon L., Woster, Patrick M., Casero, Robert A.

Journal:

Expert Reviews in Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 373 KB

english, 2013

37

Polyamine analogues targeting epigenetic gene regulation

Huang, Yi, Marton, Laurence J., Woster, Patrick M., Casero, Robert A.

Journal:

Essays in Biochemistry

Year:

2009

Language:

english

File:

PDF, 660 KB

english, 2009

38

Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1

Hazeldine, Stuart, Pachaiyappan, Boobalan, Steinbergs, Nora, Nowotarski, Shannon, Hanson, Allison S., Casero, Robert A., Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.42 MB

english, 2012

39

The re-expression of the epigenetically silencede-cadheringene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines

Murray-Stewart, Tracy, Woster, Patrick M., Casero, Robert A.

Journal:

Year:

2014

Language:

english

File:

PDF, 462 KB

english, 2014

40

Recent Advances in the Development of Polyamine Analogues as Antitumor Agents §

Casero, Robert A., Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.97 MB

english, 2009

41

S-(5'-Deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): An Irreversible Inhibitor of S-Adenosylmethionine Decarboxylase with Potent in Vitro Antitrypanosomal Activity

Guo, Junqing, Wu, Yong Qian, Rattendi, Donna, Bacchi, Cyrus J., Woster, Patrick M.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

42

Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

Candace S. Hayes, Karen DeFeo-Mattox, Patrick M. Woster, Susan K. Gilmour

Journal:

Year:

2014

Language:

english

File:

PDF, 432 KB

english, 2014

43

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease

Dewdney, Tamaria G., Wang, Yong, Liu, Zhigang, Sharma, Shiv K., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

44

Design of small molecule epigenetic modulators

Pachaiyappan, Boobalan, Woster, Patrick M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

45

Synthesis and Evaluation of Novel Cyclic Peptide Inhibitors of Lysine-Specific Demethylase 1

Kumarasinghe, Isuru R., Woster, Patrick M.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

46

99 Polyamines Mediate Helicobacter priori-Induced Gastric Carcinogenesis in Gerbils

de Sablet, Thibaut, Chaturvedi, Rupesh, Asim, Mohammad, Barry, Daniel P., Gobert, Alain P., Blanca Piazuelo, M., Casero, Robert A., Woster, Patrick M., Correa, Pelayo, Wilson, Keith T.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 228 KB

english, 2013

47

The Role of Polyamine Catabolism in Polyamine Analogue-Induced Programmed Cell Death

Hyo Chol Ha, Patrick M. Woster, James D. Yager and Robert A. Casero

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.54 MB

english, 1997

48

The Natural Polyamine Spermine Functions Directly as a Free Radical Scavenger

Hyo Chol Ha, Nilantha S. Sirisoma, Periannan Kuppusamy, Jay L. Zweier, Patrick M. Woster and Robert A. Casero

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.34 MB

english, 1998

49

P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease

Yedidi, Ravikiran S., Liu, Zhigang, Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

Journal:

Journal of Molecular Graphics and Modelling

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

50

Synthesis and biological evaluation of cyclic analogs of l-carnitine as potential agents in the treatment of myocardial ischemia

Woster, Patrick M., Murray, Wallace J.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 546 KB

english, 1986